Lethiferous effects of a recombinant vector carrying thymidine kinase suicide gene on 2.2.15 cells via a self-modulating mechanism

Figure 3 Effects of pcDNA₃-SCITK expression on morphological alterations of 2. 2.15 and HepG2 cells. Photographs a, b and c in each group exhibited respectively the cell changes on the 1^st, 3^rd and 6^th day post transfection. Lethiferous changes of 2.2.15 cells transfected with pcDNA₃-SCITK were noted initially on the 3^rd day of posttransfection and aggravated on the 6^th day after transfection, in which the majority of cells were observed shrunken, rounded in shape and even dead. However, the negative contrl HepG2 cells grew well.