Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B

Table 1 Allele frequency of HLA-DRB1 in patients with chronic and acute hepatitis B and normal heathy individuals

HLA-DRB1 allele	Normal control (n = 106)		Chronic hepatitis B (n = 52)		Acute hepatitis B (n = 30)
	PN	AF	PN	AF	PN	AF
0101/0103	1	0.47	1	0.96	1	1.67
0301*	12	5.66	18	17.31	6	10.00
0401/0411	24	11.32	13	12.50	7	11.67
0701/0702	11	5.19	8	7.69	4	6.67
0801/0804	9	4.25	6	5.77	3	5.00
0901	32	15.09	16	15.39	8	13.33
1001	2	0.94	2	1.92	1	1.67
1101/1104**	13	6.13	1	0.96	8	13.33
1201/1202	34	16.04	15	14.42	8	13.33
1301/1302	4	1.89	1	0.96	1	1.67
1303/1304	1	0.47	1	0.96	1	1.67
1401, 1404	14	6.60	6	5.77	4	6.67
1402, 1403	0	0.00	0	0.00	0	0.00
1501/1502	34	16.04	11	10.58	5	8.33
1601/1602	13	6.13	2	1.92	1	1.67
Blank	8	3.77	3	2.89	2	3.33

PN: Positive number, AF: Allele frequency. *χ² = 12.3068, Pc = 0.0074, RR = 4.15. **χ² = 11.9206, Pc = 0.0145, RR = 18.55.