Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines

Figure 4 Effects on cell cycle distribution of LoVo cells & SW480 cells treated with5-FU, CDDP or combination therapy. Both cell lines show an accumulation of G1-phase exposed to5-FU. On the contrary, CDDP mainly renders an accumulation of S-phase. Percentage of G1-and S-phase dominates alternatively in both lines treated with combination of 5-FU and CDDP.