Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines

Figure 3 Hypodiploid DNA induced by 5-FU, CDDP or a combination therapy in LoVo cells and SW480 cells. LoVo cells treated with 5-FU show an earlier presence and higher percentage of cells with hypodiploid DNA. B When exposed to CDDP, SW480 cells showed a more dramatic increase in presence of hypodiploid DNA than LoVo cells after 48 h. C When the two cell lines were exposed to 5-FU in combination with CDDP, SW480 cells have an 18% hypodiploid DNA, but not in LoVo cells in 96 h after treatment.