Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines

Figure 1 Comparison of sensitivity to 5-FU, CDDP or combination therapy in LoVo cells and SW480 cells. (A) SW480 cells show increased sensitivity to CDDP than LoVo cells at the concentrations above 16 μmol/L (Ratio of absorption is 0.64 and 0.79 at 16 μmol/L, respectively; P < 0.01). (B) The dose-effect curve tells that the cytotoxicity diminishes in combination therapy of 5-FU and CDDP in both cell lines when compared with 5-FU single-therapy (Ratio of absorption in LoVo + 5-FU, SW480 + 5-FU, LoVo + 5-FU + CDDP and SW480 + 5-FU + CDDP is 0.53, 0.54, 0.72, 0.78, respectively; P < 0.01).