DNA-PKcs subunits in radiosensitization by hyperthermia on hepatocellular carcinoma hepG2 cell line

Figure 2 DNA-PKcs activity of HepG2 cells. A: Cells were heated at 45.5 °C for 20 min and then received 40 Gy of X-rays (closed circles) or irradiated with 40 Gy of X-rays only (open circles). At various periods, DNA-PKcs activity in heated cells was inhibited, and kept at low level about 30%. The DNA-PKcs activity in both groups showed slight increase; B: After heated at 45.5 °C for 20 min, DNA-PKcs activity was still inhibited at various periods; C: DNA-PKcs activity was inhibited after exposure to heat at 45.5 °C for 5 min, even though the heat time was prolonged, DNA-PKcs activity levels still remained unchanged.