Synthesis of an enzyme-dependent prodrug and evaluation of its potential for colon targeting

Table 1 Recovery of free dexamethasone from the rat blood and GI tract at various times after administration of DSD suspensions^a,b (equivalent to 15 mg of dexmethasone per kg body weight)

th	Tμg	Recovery of dexamethasone (%)
		B	S	PSI	DSI	Ce	Co
1	5.2	nd	74	26	nd	nd	nd
3	7.3	nd	54	nd	46	nd	nd
4	14	nd	8.8	6.6	10.2	54	20.5
5	27.6	nd	9.2	5.0	13.4	54.4	18.0
6	133	nd	4.0	0.27	2.2	83	10.2
7	128	nd	4.5	nd	0.557	80	15.2
9	105	nd	12.4	3.49	3.72	62	18.2