Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis

Table 2 Comparison of cell proliferation in proximal and distal hemicrypts of normal and DMH rat colon

Parameters	Normal control		DMH
	Proximal	Distal	Proximal	Distal
Cells/hemi-crypt	34.45 ± 0.39	31.45 ± 0.2a	49.09 ± 0.65b	42.68 ± 0.53ac
Labelled cells	2.49 ± 0.16	2.74 ± 0.11	5.7 ± 0.24b	5.67 ± 0.23c
Total LI	7.2 ± 0.45	8.65 ± 0.34a	11.55 ± 0.45b	13.13 ± 0.46ac
Proliferative zone	16.75 ± 1.45	21.74 ± 1.07a	35.52 ± 1.58b	39.6 ± 1.32ac
LI of proliferative zone	59.43 ± 3.39	56.55 ± 2.13	39.84 ± 1.77b	38.89 ± 1.5c

Values expressed as mean ± SEM.

^aP < 0.05 when distal is compared to proximal in the same group,

^bP < 0.05 when DMH proximal is compared to normal proximal,

^cP < 0.05 when DMH distal compared to normal distal.