Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis

Table 1 Multivariate linear regression analyses with 2 design variables against 7 measured parameters

Response variable	Covariate	Coefficient	P-value
CPC	DMH	12.386	< 0.05
	POSITION	5.004	< 0.05
TOTLI	DMH	4.433	< 0.05
	POSITION	-1.528	< 0.05
INDLI 1	DMH	3.915	< 0.05
	POSITION	-9.006	< 0.05
INDLI 2	DMH	4.504	< 0.05
	POSITION	-2.159	0.14
INDLI 3	DMH	10.425	< 0.05
	POSITION	3.343	< 0.05
PZONE	DMH	18.169	< 0.05
	POSITION	-4.454	< 0.05
PZONELI	DMH	-18.312	< 0.05
	POSITION	1.725	0.43

CPC, cell per hemicrypt; TOTLI, total hemicrypt labelling index; INDLI 1, individual LI in compartment 1; INDLI 2 individual LI in compartment 2; INDL 3, individual LI in compartment 3; PZONE, proliferative zone; PZONELI, labelling index of proliferative zone.