Anti-inflammatory effect of cholecystokinin and its signal transduction mechanism in endotoxic shock rat

Figure 3 p38 MAPK (A) was activated by LPS and enhanced by CCK-8 in rat lung (left) or spleen (right) using Western blotting. Degradation of IκB-α in lung and spleen following LPS administration was observed and pre-administration of CCK-8 could reduce its degradation. These figures are representative of three different experiments.1. Normal control, 2 LPS (8 mg•kg⁻¹), 3. CCK-8 (40 μg•kg⁻¹) + LPS, 4. CCK-8.