Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance

Figure 3 Immunohistochemical staining of P28/Gankyrin in HCC, para-carcinoma liver tissue and SK-Hep1 cell line. (A) p28/gankyrin was moderately to intensely present in the cytoplasm of most hepatocytes in HCC tissue, and occasionally present in the nucleus of hepatocytes; (B) In contrast, p28/gankyrin was weakly present in the cytoplasm of hepatocytes in para-carcinoma liver tissue; (C) p28/gankyrin protein signals were specifically present in the cytoplasm of hepatocytes, while absent in bile duct cells, blood vein endometrial cells and other interstitial cells; (D) In SK-Hep1 cells, p28/gankyrin was mostly located in cytoplasm and occasionally in the nucleus.