Overexpression of p28/gankyrin in human hepatocellular carcinoma and its clinical significance

Figure 2 Densitometric analysis. The ratio of the optical density of p28/gankyrin mRNA to the corresponding 18 S rRNA signals was calculated and expressed as means ± SD. (A) Comparison of p28/gankyrin expression in human liver cirrhosis, para-carcinoma liver tissues and HCCs. ^aThe expression in HCCs was significantly higher than that in liver cirrhosis (P < 0.05). bThe expression in HCCs was significantly higher than that in para-carcinoma liver tissues (P < 0.01). (B) Clinicopathological significance of p28/gankyrin expression in HCCs. p28/gankyrin mRNA levels were significantly higher (P = 0.021) in portal vein thrombus group than in non-thrombus group, higher (P = 0.047) in microscopic hepatic vein involvement group than in non-hepatic vein involvement group.