Hepatoprotective role of ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice

Table 3 Effects of Ganoderma lucidum polysaccharide (GLP) on the alanine transaminase (ALT) activity and nitrite (NO₂^-) production induced by BCG-prestimulating in the presence or absence of cytokines mixture (CM) in primary cultured mice hepatocytes in vitro (¯x ± s)

Group	ALT (U·L-1)	NO2- (μmol·L-1)
Control	11.52 ± 1.41b	1.41 ± 0.72a
BCG	17.87 ± 3.41	3.52 ± 1.72
BCG + GLP (50 mg·k-1)	21.30 ± 2.87	3.95 ± 1.27
BCG + GLP (200 mg·k-1)	18.03 ± 2.24	3.24 ± 1.08
BCG + Cytokines Mixture (CM)	46.34 ± 4.17b	13.53 ± 5.58b
BCG + CM + GLP (50 mg·k-1)	23.98 ± 6.33ad	4.11 ± 2.26d
BCG + CM + GLP (200 mg·k-1)	20.61 ± 3.74d	3.49 ± 1.38d

^aP < 0.05,

^bP < 0.01 compared with BCG-pretreated group; ^cP < 0.05,

^dP < 0.01 compared with BCG + CM group. n = 7 mice. (3 wells for each treatment in each experiment).