Loss of heterozygosity on long arm of chromosome 22 in sporadic colorectal carcinoma

Table 3 The relationship between clinicopathological features and LOH of 5 loci on chromosome 22

		D22S315		D22S280		D22S283		D22S423		D22S274
		N	L	N	L	N	L	N	L	N	L
Gender	Male	28	6	19	7	21	7	22	5	13	8
	Female	28	6	18	13	22	10	19	10	18	8
Age	> 60	41	9	24	19	31	15	30	11	22	13
	≤ 60	15	3	13	1	12	2	11	4	9	3
Location	Proximal Colon	21	4	13	7	18	5	14	6	15	2
	Distal Colon	13	4	12	4	11	5	12	6	7	5b
	Rectum	22	4	12	9	14	7	15	3	9	9a
Gross Pattern	Massive	23	4	16	8	19	7	16	6	11	5
	Ulcerative	21	7	15	9	14	7	18	7	14	8
	Encroaching	12	1	6	3	10	3	7	2	6	2
Size	≥ 5 (cm)	25	7	14	11	20	8	18	10	17	5
	< 5 (cm)	31	5	23	9	23	9	23	5	14	11
LN Metastasis	LN (+)	36	9	26	13	31	11	26	11	24	7
	LN (-)	20	3	11	7	12	6	15	4	7	9
Differentiation	Well	15	3	8	6	13	3	11	5	7	5
	Moderately	28	3	17	10	19	10	24	5	15	7
	Poorly	3	3	4	2	3	1	1	2	3	3
	Mucinous	10	3	8	2	8	3	5	3	6	1
Dukes stage	A	3	3	1	3	3	2	3	2	2	4
	B	17	1	10	4	9	4	12	2	5	5
	C	26	4	18	11	22	9	19	7	16	5
	D	10	4	8	2	9	2	7	4	8	2

^aP = 0.018, the LOH frequency of rectal cancer vs that of proximal colon cancer;

^bP = 0.015, the LOH frequency of cancer in distal colon and rectum vs that of proximal colon cancer