Rapid screening mitochondrial DNA mutation by using denaturing high-performance liquid chromatography

Figure 3 The representative DHPLC chromatograms of variant fragments detected blindly for patients with gastric cancinoma in D-loop of mtDNA. The chromatogram of tumor tissue is visibly different to that of its counter-part non-tumor tissue. The variant cases are listed on the top of each DHPLC chromatogram. DF1, DF2, DF3 and DF4 represent the tested fragments of D-loop respectively. T: tumor tissues; N: non-tumor tissues.