Detection of anti-preS1 antibodies for recovery of hepatitis B patients by immunoassay

Figure 6 The profiles of serologic markers during acute chronic HBV infection with immuno-diagnosis for preS1 antigen and anti-preS1(21-119 aa) antibodies. A: Typical serologic profile of HBV markers during acute infection, with disappearance of preS1 antigen and seroconversion to anti-preS1(21-119 aa) antibodies; elimination of HBV-DNA in 2-4 mo from the appearance of antibodies; B: Chronic patients with HBeAg+ serologic profile; high level of preS1 antigen and HBV-DNA but absence of anti-preS1(21-119 aa) antibodies; C: Chronic patients with anti-HBe+ serologic profile; low level of preS1 domain and HBV-DNA and absence of anti-preS1(21-119 aa) antibodies. D: One patient persisting of HBsAg, HBeAg and preS1 for almost 3 years until treated with Lamivudine. Appearance of anti-preS1(21-119 aa) antibodies with simultaneous health improvement; disappearance of HBV-DNA and declining level of preS1 antigen in serum. OD₄₅₀ value of Y axis (‘●’ preS1 antigen and ‘○’ anti-preS1 antibody was mean value of inpatients in every group; different shade (■) in the rectangle (A) represented different level of HBV-DNA in patients.