Review
Copyright ©The Author(s) 2002.
World J Gastroenterol. Feb 15, 2002; 8(1): 13-20
Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.13
Table 4 The effect of glutamine, growth hormone, and a modified diet on patients with short-bowel syndrome
AuthorsDesign of StudyTreatmentNumber and Type of PatientsAverage Length of Remnant Bowel 43Results
Byrne et al[65].Uncontrolled study.GH 0.11 mg·kg-1·d-1, glutamine47 patients that werepatients with aAt the end of the study 57% of the
Patients admitted to0.16 g·kg-1·d-1ªª by the parenteralchronically dependentcolonic remnantpatients no longer needed TPN, 30%
hospital and treated forroute with up to 30 g·d-1 by theon parenteral nutritionhad(50 ± 7)cm[4].had reduced TPN requirements, and
21 d.enteral route, and a diet containingpatients with6% required approximately the same
60% of total calories asno colon hadamount of TPN as they did at the start
carbohydrate, 20% as fat and 20%(102 ± 24)cm.of the study.
from protein.One year later 40% of the patients no
longer needed TPN, 40% had reduced
TPN requirements, and 20% required
approximately the same amount of TPN
as they did at the start of the study
Scolapio[66]Double-blind, placeboGH 0.14 mg·kg-1·d-1, glutamine8 patients that were71 cm2 patientsTreatment led to a significant increase
Scolapio et al[67].controlled, randomized0.63 g·kg-1·d-1 by oral route, and adependent on parenteralhad colonicin bodyweight and lean body mass, a
crossover study. Patientsdiet containing 60% total caloriesnutrition for an averagecontinuity.significant decrease in percent body fat
were treated for 21 d asas carbohydrate, 20% as fat andof 12.9 years.and induced peripheral edema.
out-patients.20% as protein.All parameters returned to baseline
levels within 14 d of stopping treatment.
Treatment had no significant effect on
intestinal villus height or crypt depth.
Szkudlarek et al[68].Double-blind, placeboGH 0.14 mg·kg-1·d-1, glutamine8 patients that were104 cm.4 patientsNo significant effect of treat ment on
controlled, randomized30 g·d-1 by oral route anddependent on parenteralhad colonicabsorption of energy, carbohydrate,
crossover study. Patientsglutamine-enriched parenteralnutrition for an averagecontinuity.nitrogen, wet weight, sodium, potassium,
were treated for 28 d asnutrition (17% of nitrogenof 7 years .calcium or magnesium. Treatment induced
out-patients.as glutamine).adverse effects.