Copyright
©The Author(s) 2002.
World J Gastroenterol. Feb 15, 2002; 8(1): 13-20
Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.13
Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.13
Authors | Design of Study | Treatment | Number and Type of Patients | Average Length of Remnant Bowel 43 | Results |
Byrne et al[65]. | Uncontrolled study. | GH 0.11 mg·kg-1·d-1, glutamine | 47 patients that were | patients with a | At the end of the study 57% of the |
Patients admitted to | 0.16 g·kg-1·d-1ªª by the parenteral | chronically dependent | colonic remnant | patients no longer needed TPN, 30% | |
hospital and treated for | route with up to 30 g·d-1 by the | on parenteral nutrition | had(50 ± 7)cm[4]. | had reduced TPN requirements, and | |
21 d. | enteral route, and a diet containing | patients with | 6% required approximately the same | ||
60% of total calories as | no colon had | amount of TPN as they did at the start | |||
carbohydrate, 20% as fat and 20% | (102 ± 24)cm. | of the study. | |||
from protein. | One year later 40% of the patients no | ||||
longer needed TPN, 40% had reduced | |||||
TPN requirements, and 20% required | |||||
approximately the same amount of TPN | |||||
as they did at the start of the study | |||||
Scolapio[66] | Double-blind, placebo | GH 0.14 mg·kg-1·d-1, glutamine | 8 patients that were | 71 cm2 patients | Treatment led to a significant increase |
Scolapio et al[67]. | controlled, randomized | 0.63 g·kg-1·d-1 by oral route, and a | dependent on parenteral | had colonic | in bodyweight and lean body mass, a |
crossover study. Patients | diet containing 60% total calories | nutrition for an average | continuity. | significant decrease in percent body fat | |
were treated for 21 d as | as carbohydrate, 20% as fat and | of 12.9 years. | and induced peripheral edema. | ||
out-patients. | 20% as protein. | All parameters returned to baseline | |||
levels within 14 d of stopping treatment. | |||||
Treatment had no significant effect on | |||||
intestinal villus height or crypt depth. | |||||
Szkudlarek et al[68]. | Double-blind, placebo | GH 0.14 mg·kg-1·d-1, glutamine | 8 patients that were | 104 cm.4 patients | No significant effect of treat ment on |
controlled, randomized | 30 g·d-1 by oral route and | dependent on parenteral | had colonic | absorption of energy, carbohydrate, | |
crossover study. Patients | glutamine-enriched parenteral | nutrition for an average | continuity. | nitrogen, wet weight, sodium, potassium, | |
were treated for 28 d as | nutrition (17% of nitrogen | of 7 years . | calcium or magnesium. Treatment induced | ||
out-patients. | as glutamine). | adverse effects. |
- Citation: Platell CFE, Coster J, McCauley RD, Hall JC. The management of patients with the short bowel syndrome. World J Gastroenterol 2002; 8(1): 13-20
- URL: https://www.wjgnet.com/1007-9327/full/v8/i1/13.htm
- DOI: https://dx.doi.org/10.3748/wjg.v8.i1.13