Identification of the epitopes on HCV core protein recognized by HLA-A2 restricted cytotoxic T lymphocytes

Table 3 CTL activity induced by predicted peptides on HCV C protein

Subject	HLA type				51Cr-release (%lysis)
	A		B		①	②	④	⑤
Experiment
Li	2	31	51	16	-2.6	9.6	0.5	NT
Zhang	2	11	8	27	0.4	NT	2.4	6.9
Tang	2	33	44	55	-3.8	5.1	3.3	37.5
Zhang	2	11	62	35	-1.1	9.8	8.4	12.2
Healthy control
Zheng	2	11	62	39	-2.9	8.0	6.8	-0.2
Wang	2	24	61	46	0.2	NT	3.7	10.0
Patient control
Li	11		62	35	-2.6	2.6	2.3	-1.8
Zhu	3	33	17	35	-2.5	1.6	0	2.5

CTL activity induced by peptides at E/T ratio of 50:1; NT: No test; ①, ②, ④ and ⑤ represent YLLPRRGPRL (core 35-44), NLGKVIDTL (core 118-126), DLMGYIPLV (core 132-140) and ALAHGVRAL (core 150-158), respectively.