APC and K-ras gene mutation in aberrant crypt foci of human colon

Table 2 APC gene mutation

DNA	Region	Codon	Mutation	Amino acid exchange
N 3 CRC	A	1354	TTT→TTA	Phe→Leu
N17 CRC	A	1309	GAA→TAA	Stop cocon
N14 CRC	B	1389	TCT→TTT	Ser→Phe
N 5 CRC	B	1357	GGA→AGA	Gly→Arg
N21 CRC	B	1365	GGT→GGC	nonsense
N26 CRC	B	1398	AGT→ACT	Ser→Thr
N28 CRC	C	1465	GTG→GCG	Val→Ala
N33 CRC	D	1547	GAA→TAA	Stop codon
Tubular villous adenoma	A	1301	ins1 A	Stop codon
Villous adenoma	A	1309	GAA→TAA	Stop codon
Villous adenoma	C	1490	ins8 TTATTACA	Frame shift
Tubular villous adenoma	B	1367	CAG→CAC	Gln→His
ACF	A	1309	GAA→TAA	Stop codon