Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice

doi:10.3748/wjg.v7.i3.345

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Jun 15, 2001 (publication date) through Feb 3, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 2001; 7(3): 345-351
Published online Jun 15, 2001. doi: 10.3748/wjg.v7.i3.345

Table 3 Therapeutic efficacy of AFP S-ODNs in SMMC-7721 hepatoma bearing nude mice

Group (mg/day × day)	Mean tumor weight (mg)								Toxic deaths	AFP content (% inhibition)
Group (mg/day × day)	0*	2	4	6	8	10	12	14	Toxic deaths	AFP content (% inhibition)
Control (0)	96.7 ± 51.1	191.4 ± 48.3	336.9 ± 67.8	504.8 ± 80.2	636.3 ± 68.8	823.9 ± 187.6	1056.7 ± 182.0	1201.6 ± 208.0	0/6	-
Antisense (0.25 ± 8)	83.1 ± 33.7	145.2 ± 43.8 (24.2)	215.8 ± 49.6 (35.9)^a	286.5 ± 49.2 (43.2)^a	356.7 ± 52.5 (43.9)^a	520.0 ± 56.1 (36.9)^a	653.1 ± 128.8 (38.2)^a	776.6 ± 61.3 (35.4)^a	0/6	68.9^a
Antisense (0.50 ± 8)	84.8 ± 34.6	130.3 ± 36.9 (31.9)^a	202.3 ± 47.9 (39.9)^a	254.2 ± 43.2 (49.6)^a	310.8 ± 56.9 (51.2)^a	449.9 ± 108.3 (45.4)^a	593.9 ± 72.3 (43.8)^a	737.3 ± 146.7 (38.6)^a	0/6	73.8^a
Sense (0.25 ± 8)	100.5 ± 33.5	201.4 ± 44.2	339.1 ± 71.1	510.4 ± 114.1	629.6 ± 109.4	829.5 ± 164.5	1034.9 ± 198.1	1191.9 ± 181.3	0/6	3.4
Sense (0.50 ± 8)	86.9 ± 25.6	187.7 ± 42.3	359.7 ± 59.6	509.5 ± 111.8	659.7 ± 101.7	837.7 ± 147.3	1011.0 ± 142.9	1232.3 ± 149.0	0/6	0

Mice were treated the eighth day after tumor cell implantation with S-ODNs following different schedules. Untreated mice received normal saline only. *Time after S-ODN administration (day). Values in parentheses: percent inhibition. Each value represents mean ± SD of 6 samples.

^aP < 0.05 (Mann-Whitney U test) compared with untreated mice and mice treated with sense S-ODNs.

Citation: Wang XW, Yuan JH, Zhang RG, Guo LX, Xie Y, Xie H. Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice. World J Gastroenterol 2001; 7(3): 345-351
URL: https://www.wjgnet.com/1007-9327/full/v7/i3/345.htm
DOI: https://dx.doi.org/10.3748/wjg.v7.i3.345