Stress kinase inhibition modulates acute experimental pancreatitis

Figure 3 Effects of CEP1347 and SB203580 on biochemical parameters of pancreatitis. Animals were treated with 10 μg/kg cerulein iv and sacrificed 2 h later. As indicated rats were also pretreated with 30 mg/kg CEP1347 and/or SB203580 4 h prior to cerulein injections. Serum amylase levels (A), serum lipase levels (B), dry to pancreatic total weight ratio (C) and pancreatic active trypsin content (D) were determined after sacrifice. Kinase inhibitors had no apparent effect on the cerulein-induced increase of serum digestive enzyme levels. However, CEP1347 reduced the cerulein-induced increase of pancreatic water content and this effect was blocked by simultaneous treatment with SB203580. SB203580 further increased cerulein induced pancreatic active trypsin content and this effect was blocked by simultaneous treatment with CEP1347.