HCV-RNA positivity in peripheral blood mononuclear cells of patients with chronic HCV infection: does it really mean viral replication?

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Apr 15, 2001 (publication date) through Aug 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 15, 2001; 7(2): 228-234
Published online Apr 15, 2001. doi: 10.3748/wjg.v7.i2.228

Table 3 Detectability of HCV-RNA in PBMC of healthy donors after incubation with different dilutions of HCV-RNA positive plasma

Patients	HCV concentration (copies/mL)				PMBC of healthy donor	Detectability of HCV-RNA in PBMC of healthy donors
Patients	Undiluted sample	1:4	1:16	1:64	PMBC of healthy donor	Before incubation	After incubation dilution step (copies/mL)
SG	119271	29818	7454	1863	BS	n.d.	Undiluted (119271)
UP	337539	84385	21096	5274	VM	n.d.	1:16 (21096)
EZ	77518	19290	4822	1206	NN	n.d.	1:4 (19290)

Citation: Meier V, Mihm S, Braun PW, Ramadori G. HCV-RNA positivity in peripheral blood mononuclear cells of patients with chronic HCV infection: does it really mean viral replication? World J Gastroenterol 2001; 7(2): 228-234
URL: https://www.wjgnet.com/1007-9327/full/v7/i2/228.htm
DOI: https://dx.doi.org/10.3748/wjg.v7.i2.228