Activity of boanmycin against colorectal cancer

Table 2 Inhibitory effect of BAM, MMC and 5-Fu on the growth and tumor cell mitosis of human colon cancer HT-29 xenografts in nude mice*

Drug	Dose** (mg/kg)	No. of mice	Tumor weight (g) x-± s	Inhibitory rate (%)	Necrotic ratio of umors△(%)	Mitotic figures△△
						x-± s	(%)
Control		5	0.804 ± 0.173		35b	104 ± 12	100
BAM	10	5	0.148 ± 0.059	82	67	41 ± 4	39b
MMC	1	5	0.376 ± 0.174	53a	43b	107 ± 12	103
5-FU	27	5	0.707 ± 0.168	12b	35b	130 ± 17	130

*Treatment was started on day 9 after tumor transplantation, ip., twice a week, with a total of 10 injections;

^**Drugs were administered at equitoxic doses (1/9 LD50);

^△Ratio of necrotic areas in whole section of the tumor.

^△△Number of mitotic figures in 10 optical fields of the section of tumor.

^aP < 0.05, vs BAM group;

^bP < 0.01, vs BAM group.