Inhibitory effects of RRR-α-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice

Table 3 Inhibitory effects of VES on the size of B(a)P-induced forestomach tumors (x^-± s_x-)

Groups	No.of mice	Vol/tumor (mm3)	Total tumor Vol/mouse (mm3)
1. Succinic acid	12	0	0
2. Succinic acid + B(a)P	9	31.5 ± 4.51	169.5 ± 33.42
3. B(a)P	10	27.8 ± 8.52	150.2 ± 20.93
4. 1.25 g/kgVES + B(a)P	11	31.7 ± 8.62 (0)	54.8 ± 8.84b (63.5)
5. 2.5 g/kgVES + B(a)P	13	17.6 ± 5.54 (36.7)	28.4 ± 8.32b
6. 20 mg/kgVES (ip) + B(a)P	10	21.7 ± 2.13 (21.9)	23.9 ± 16.05b (84.1)

^bCompared with the B(a)P group (group 3), P < 0.01 (using Student’s t test)ª¤Numbers in parentheses are % of inhibition of tumors compared to group 3.