Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis

Table 3 Serum hyaluronic acid level and liver hydroxylproline content in CCl₄-induced specimens after 8 weeks treatment

Groups	HA (μg/L)	Hyp (mg/g liver dry weight)
Normal control group	147.64 ± 19.28	2.43 ± 0.33
Fibrotic model group	900.04 ± 508.84	10.01 ± 3.23
Colchicine treatment group	745.57 ± 170.44a	6.90 ± 1.70
High-dose IFN-γ group	482.05 ± 210.57	2.83 ± 1.18
Medium-dose IFN-γ group	765.51 ± 586.65a	3.59 ± 1.22bd
Low-dose IFN-γ group	981.52 ± 509.95	4.80 ± 1.62

^aP < 0.05 vs fibrotic model group;

^bP < 0.01 vs fibrotic model group; ^cP < 0.05 vs colchicines treatment group;

^dP < 0.01 vs colchicines treatment group.