Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis

Table 1 Histological grading and staging in CCl₄-induced specimens after 8 week treatment

Groups	2g*	2s*	SSS△
Normal control group	1.00 ± 0.00	1.00 ± 0.00	0
Fibrotic model group	9.20 ± 5.01	10.40 ± 5.06	14.60 ± 7.82
Colchicine treatment group	10.40 ± 5.06	7.40 ± 4.99a	10.60 ± 3.34a
High-dose IFN-γ group	9.60 ± 3.37	3.00 ± 1.05bc	5.10 ± 2.88bc
Medium-dose IFN-γ group	6.00 ± 4.22	5.60 ± 4.20bc	7.70 ± 3.53bc
Low-dose IFN-γ group	7.60 ± 4.79	5.40 ± 2.32bc	8.00 ± 3.30bc

*Scheuer’s criteria;

^△Chevallier’s criteria;

^aP < 0.05 vs fibrotic model group;

^bP < 0.01 vs fibrotic model group;

^cP < 0.05 vs colchicines treatment group.