Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions: H. pylori infection, histological types and staging

Table 5 Expressions of p53, p16, Bcl-2, and COX-2 proteins in GC related to tumor staging and histological types (n, %)

Lesion	n	p53	p16	Bcl-2	COX-2
Type
Intestinal	24	14 (58.3)	9 (37.5)	18 (75.0)a	16 (66.7)
Diffuse	6	3 (30.0)	2 (33.3)	1 (16.7)	4 (66.7)
Stage of GC
Early	5	2 (40.0)	2 (40.0)	4 (80.0)	1 (20.0)
Advanced	25	15 (60.0)	9 (36.0)	15 (60.0)	19 (76.0)a
Grade of differentiation
High or middle	14	6 (42.9)	6 (42.9)	12 (85.7)	8 (57.1)
Low or not	10	8 (80.0)	3 (30.0)	7 (70.0)	8 (80.0)
Lymph node metastasis
No	4	2 (50.0)	2 (50.0)	3 (75.0)	1 (16.7)
Yes	26	15 (57.7)	9 (34.6)	16 (61.5)	19 (79.2)a

^aP < 0.05 Bcl-2: Intestinal-Diffuse; COX-2: Advanced-Early, Lymph node metastasis Yes-No.