Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions: H. pylori infection, histological types and staging

Table 3 The expression intensity of p53, p16, Bcl-2, and COX-2 proteins in gastric mucosal lesions with H. pylori infection (n)

Lesion	Hp	p53				p16				Bcl-2				COX-2
		-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++
CSG	+					13	17	13	6	45	3	1
	-					4	13	15	3	32	2	1
CAG	+					14b	12	5		25	2	4		28	3
	-					3	5	9	8	22	2	1		23	2
IM	+		1			21b	7	4		10a	4	10	8	16a	5	11
	-					14	4	15	13	35	6	5		41	4	1
Dys	+	15	4	2		16a	2	3		2a	2	11	6	8a	3	10
	-	24	2	2		13	2	8	5	11	9	5	3	23	3	2
GC	+	16	6	8	3	22	4	5	2	8	6	11	8	7	2	17	7
	-	16	4	6	1	15	5	6	1	11	5	9	2	8	4	12	3

^bP < 0.01 p16 (CAG or IM) Hp+-Hp-; ^aP < 0.05 p16 (Dys) Hp+-Hp-; Bcl-2 or COX-2 (IM or Dys) Hp+-Hp-.