Stimulation by nizatidine, a histamine H2-receptor antagonist, of duodenal HCO3- secretion in rats: relation to anti-cholinesterase activity

Figure 6 Effects of nizatidine and famotidine on histamine-induced gastric acid secretion in rats. A rat stomach mounted in an ex-vivo chamber was perfused with saline, and the acid secretion was measur ed by adding 100 mM NaOH to the reservoir. The acid secretion was stimulate d by i.v. infusion of histamine (4 mg/kg/h), while nizatidine (10 and 30 mg/kg) or famotidine (10 mg/kg) was administered i.v. as a single injection 1 h after the onset of histamine infusion, when the acid secretion had reached a plateau. Data are presented as the means ± SE of values determined every 15 min from 5 rats. ^aSignificant difference from controls, P < 0.05.