Stimulation by nizatidine, a histamine H2-receptor antagonist, of duodenal HCO3- secretion in rats: relation to anti-cholinesterase activity

Figure 3 Effect of cisapride on duodenal HCO₃^- secretion in rats. The HCO₃^- secretion was measured by perfusing a duodenal loop with saline and by adding 10 mM HCl to the reservoir. Cisapride (3 mg/kg) was administered i.v. as a single injection after the basal secretion had well stabilized, and the HCO₃^- secretion was measured for 2 h. Data indicate total HCO₃^- output obtained for 2 h after administration of cisapride, and represent the means ± SE from 6 rats.