Stimulation by nizatidine, a histamine H2-receptor antagonist, of duodenal HCO3- secretion in rats: relation to anti-cholinesterase activity

Figure 2 Effects of neostigmine, carbachol and famotidine on duodenal HCO₃^- secretion in rats. The HCO₃^- secretion was measu red by perfusing a duodenal loop with saline and by adding 10 mM HCl to the reservoir. Neostigmine (0.03 mg/kg), carbachol (0.01 mg/kg) or famotidine (10 mg/kg) was administered i.v. as a single injection after the basal secretion had well stabilized, and the HCO₃^- secretion was measured for 2 h. Data are expressed as % of basal values and represent the means ± SE of values determined every 15 min from 6 rats. Lower panel shows △ increase of HCO₃^- output for 2 h. Data are presented as the means ± SE from 6 rats. ^aSignificant difference from controls, P < 0.05.