Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models

Table 1 Comparison of TNF-α, ALT and AST at corresponding time in different groups (n = 5, x^-± s)

	1.5 h			3.5 h			6 h			9 h
	TNF	ALT	AST	TNF	ALT	AST	TNF	ALT	AST	TNF	ALT	AST
1	13.9 ± 15.0	39.6 ± 10.3	124.0 ± 17.0	18.8 ± 15.2	40.1 ± 6.0	129.6 ± 33.5	15.9 ± 15.9	41.5 ± 5.4	100.1 ± 24.3	21.9 ± 16.4	41.4 ± 6.6	115.6 ± 16.8
2	16.0 ± 16.0	40.3 ± 6.0	95.7 ± 37.5	10.1 ± 16.2	40.8 ± 12.8	118.4 ± 40.1	28.0 ± 21.1	46.8 ± 2.41	35.4 ± 62.4	25.4 ± 29.7	47.3 ± 9.0	100.2 ± 35.5
3	32.1 ± 14.6	53.7 ± 11.2	53.1 ± 21.1	12.3 ± 17.4	43.6 ± 6.5	52.4 ± 23.0	50.8 ± 43.3	39.2 ± 10.4	63.0 ± 20.1	44.4 ± 31.6	47.5 ± 15.4	58.2 ± 30.0
4	141.7 ± 96.5a	36.6 ± 9.8	110.9 ± 49.1	87.8 ± 51.3	47.2 ± 23.5	75.2 ± 45.7	51.1 ± 25.4	52.3 ± 20.4	119.4 ± 84.7	50.1 ± 19.3	56.5 ± 25.6	110.1 ± 85.8
5	213.5 ± 81.7a	47.2 ± 112	223.0 ± 85.0	184.3 ± 94.0	150.1 ± 17.8	230.1 ± 82.9	147.8 ± 103.1a	268.3 ± 153.8a	511.5 ± 412.0a	119.5 ± 98.4	684.3 ± 380.8a	644.4 ± 164.6abcd
6	308.6 ± 89.9a	89.1 ± 37.1	285.3 ± 138.4	290.5 ± 109.7a	127.3 ± 70.1a	344.5 ± 140.1a	208.9 ± 107.8a	540.2 ± 176.2a	602.1 ± 208.6a	158.6 ± 77.3a	978.2 ± 319.8a	1105.7 ± 714.5abcd
7				32.7 ± 18.0	46.0 ± 13.4	108.6 ± 36.0	36.3 ± 27.0	48.4 ± 14.7	129.8 ± 50.3

Comparing of results with controls at the corresponding time.

^aP < 0.05 Comparing of each other group at the different time. TNF-α:

^bP < 0.05; ALT:

^cP < 0.05; AST:

^dP < 0.05.