Participation of CD45, NKR-P1A and ANK61 antigen in rat hepatic NK cell (pit cell)-mediated target cell cytotoxicity

Figure 2 Effect of the mAbs on pit cell-mediated CC531s (A), YAC-1 (B) and P81 5 (C) target cell cytolysis. ⁵¹Cr-labeled target cells were incubated at an E:T ratio of 10:1 with freshly isolated pit cells in the absence or prese nce of the mAbs. (A), Cytolysis of CC531s cells was measured in an 18h ⁵¹Cr-release assay. (B), Cytolysis of YAC-1 cells was measured in a 4-h ⁵¹Cr-release assay. (C), Cytolysis of P815 cells was measured in a 4-h ⁵¹Cr-release assay. Values are mean ± SD from four different experiments. ^aP < 0.05, ^bP < 0.01 vs the control