Lactosamination of liposomes and hepatotropic targeting research

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Aug 15, 2000 (publication date) through Jul 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 15, 2000; 6(4): 593-596
Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.593

Table 3 Inhibitory effect on HBeAg expression in 2.2.15 cells of di fferent types of interferons

Treatment	Inhibitory effect on HBeAg expression (%)
Treatment	3 days	6 days	9 days	12 days
Liposomes	0	1.8	0	0
L-HSA-Liposomes	0	0	0	0
IFN 0.08 MU^a	0	4.7	12.7	2.3
CL-IFN 0.08 MU^b	0	0	22.8	5.8
LL-IFN 0.08 MU	44.8	60.7	43.5	45.5
LL-IFN 0.04 MU	6.8	47.4	28.6	12.1
LL-IFN 0.02 MU	0	24.6	23.8	4.6
LL-IFN 0.01 MU	0	4.8	15.4	5.2

IFN: interferon; CL-IFN: interferon entraped in conventional liposomes; LL-IFN: interferon entraped in L-HSA-liposomes. Compared with LL-IFN 0.08 MU:

^aP = 0.003,

^bP = 0.015

Citation: Chen YP, Zhang L, Lu QS, Feng XR, Luo KX. Lactosamination of liposomes and hepatotropic targeting research. World J Gastroenterol 2000; 6(4): 593-596
URL: https://www.wjgnet.com/1007-9327/full/v6/i4/593.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.i4.593