Lactosamination of liposomes and hepatotropic targeting research

Table 2 Tissue distribution of ¹³¹I labeled L-HSA-liposomes in rat, after L-HSA pre-injection

Rat No.	Tissue distribution in vivo (cpm per gram tissue)
	Liver	Spleena	Kidneyb	Heartc	Lungd
1	34682.0	35187.6	5535.7	2474.2	6368.0
2	20587.4	19791.1	4541.8	2277.2	8507.7
3	24288.8	27297.1	4564.4	2089.5	7280.7
4	33733.1	17637.5	5560.3	2698.3	12561.1
5	25600.9	18994.5	6999.2	3227.0	11087.1
Average	27778.4	23781.6	7699.1	2553.2	8679.4

Fifteen min after L-HAS pre-injection, ¹³¹I labeled L-HSA-liposomes were injected into rats. Radioactivity in different tissues was determined 40 min af ter injection as described in Materials and methods. Compared with liver:

^aP = 0.38;

^bP = 4.35 × 10^-5;

^cP = 1.66 × 10^-5;

^dP = 2.52 × 10^-4