Alterations in gastric mucin synthesis by Helicobacter pylori

Table 2 Histochemical staining of mucins in gastric biopsy specimens

Antigen		H.pylori negative	H.pylori positive
MUC5AC	% Stained*a, intensity score (surface)	(69.8% ± 3.5%), 2.8 ± 0.1	(51.2% ± 5.7%), 2.6 ± 0.1
MUC6	% Stained**a, intensity score (surface)a	4%, 0.1 ± 0.1	72%, 1.8 ± 0.2
Le\ + b	% Stained**a, intensity score (surface)a	63%, 0.9 ± 0.2	96%, 1.9 ± 0.2
Paradoxical ConA	% Stained**a, intensity score (surface)a	18%, 0.4 ± 0.2	79%, 2.1 ± 0.3
LeX	% Stained**a, intensity score (surface)a	4%, 0.4 ± 0.4	59%, 1.0 ± 0.2
MUC1	Intensity score (surface), intensity score(glands)	2.6 ± 0.2, 1.7 ± 0.1	2.7 ± 0.1, 1.4 ± 0.2
Sialyl Tn	Intensity score (surface), intensity score (glands)a	1.8 ± 0.2, 1.9 ± 0.1	1.6 ± 0.1, 1.4 ± 0.1

^*% of surface epithelium stained; ^**% of patients with surface staining;

^aP < 0.05, H.pylori positive vs H.pylori negative