Alterations in gastric mucin synthesis by Helicobacter pylori

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Aug 15, 2000 (publication date) through Sep 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 15, 2000; 6(4): 475-482
Published online Aug 15, 2000. doi: 10.3748/wjg.v6.i4.475

Table 1 Human mucin genes

Gene	Locus	mRNA size	Tandem Repeats	Other structural features	Expression in normal tissues
MUC1	1q21-24	4-7 kb	20 AA	Transmembrane	Most epithelia
MUC2	11p15.5	14-16 kb	23 AA, -16 AA	D-domains, cystine knot	Colon > small intestine > respiratory tract
MUC3	7q22	16-17.5 kb	17 AA, 59 AA	Cystine knot	Small intestine > colon, gall bladder
MUC4	3q29	16.5-24 kb	16 AA		Respiratory tract, cervix > GI tract
MUC5AC	11p15.5	17-18 kb	8 AA	D-domains, cystine knot	Stomach (surface) > respiratory tract
MUC5B	11p15.5	17.5 kb	29 AA, interrupted	D-domains, cystine knot	Respiratory tract, salivary gland, cervix > GI tract
MUC6	11p15.5	16.5-18 kb	169 AA	Cystine knot	Stomach (glands), gall bladder
MUC7	4	2.4 kb	23 AA	No homology to large mucins	Salivary glands
MUC8	12q24.3	-9 kb	18 AA, 41 AA	Not Thr/Ser rich	Trachea

Citation: Byrd JC, Bresalier RS. Alterations in gastric mucin synthesis by Helicobacter pylori. World J Gastroenterol 2000; 6(4): 475-482
URL: https://www.wjgnet.com/1007-9327/full/v6/i4/475.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.i4.475