Pharmacokinetics of traditional Chinese syndrome and recipe: a hypothesis and its verification (I)

Table 5 Pharmacokinetic parameters of TMP in serum after oral admini stration of LW or LWandSM extracts to rats mean ± SEM (n = 6)

Parameter	LW	LWandSW
α (h-1)	1.928 ± 0.719	2.328 ± 0.719
β (h-1)	0.479 ± 0.205	0.479 ± 0.289
Ka (h-1)	19.58 ± 4.139	11.508 ± 2.821a
K10 (h-1)	1.090 ± 0.502	0.788 ± 0.255
K12 (h-1)	0.470 ± 0.160	0.205 ± 0.092
T1/2α (h-1)	0.354 ± 0.101	0.298 ± 0.223
T1/2β (h-1)	1.448 ± 0.880	1.447 ± 0.901
AUC (μg·h·m L-1)	1.273 ± 0.255	0.836 ± 0.168b
VC/F (L/kg)	9.665 ± 1.810	7.390 ± 1.089a

^aP < 0.05;

^bP < 0.01 vs LW.