Pharmacokinetics of traditional Chinese syndrome and recipe: a hypothesis and its verification (I)

Table 4 Pharmacokinetic parameters of FA in serum after intravenous administration of sodium ferulate (5 mg/kg) in healthy rabbit and rabbit with general blood stasis syndrome (^-x±s, n = 6)

Parameter	RMBSS	Healthy rabbit
K12 (h-1)	1.01 ± 0.86	1.62 ± 1.18
K21 (h-1)	1.45 ± 0.99	2.47 ± 0.99
Kel (min-1)	4.49 ± 1.10a	7.37 ± 1.40
T1/2α (h)	0.12 ± 0.10	0.07 ± 0.02
T1/2β (h)	0.62 ± 0.12b	0.36 ± 0.09
AUC (μg·h·m L-1)	5.67 ± 2.35b	2.76 ± 0.82
Cl (L·kg-1)	0.88 ± 0.55	1.81 ± 0.95
VFC (L/kg)	0.71 ± 0.03	0.95 ± 0.22

^aP < 0.05;

^bP < 0.01 vs healthy rabbit. Mean ± SEM, n = 6