Pharmacokinetics of traditional Chinese syndrome and recipe: a hypothesis and its verification (I)

Table 3 Pharmacokinetic parameters of TMP in serum after oral admin istration of TMPP (10 mg/kg) to healthy rats and RMSDS with or without SJZD treatment

Parameter	Healthy rat	RMSDS	SJZD
α (h-1)	2.83 ± 0.70	0.38 ± 0.09b	2.33 ± 0.65
β (h-1)	0.22 ± 0.02	0.06 ± 0.30b	0.24 ± 0.05
Ka (h-1)	5.41 ± 1.91	13.61 ± 2.56	5.28 ± 1.39
K10 (h-1)	0.88 ± 0.20	0.24 ± 0.07b	0.82 ± 0.11
K12 (h-1)	1.45 ± 0.47	0.11 ± 0.02b	1.39 ± 0.68
K21 (h-1)	0.72 ± 0.22	0.11 ± 0.02b	0.77 ± 0.18
t1/2a (h)	0.14 ± 0.09	0.05 ± 0.04b	0.16 ± 0.10
t1/2α (h)	0.27 ± 0.11	1.92 ± 0.44b	0.31 ± 0.09
t1/2β (h)	3.19 ± 0.39	13.35 ± 5.92b	3.21 ± 0.28
AUC (μg·h·m L-1)	5.20 ± 2.57	24.88 ± 9.76b	5.11 ± 6.81
Tp (h)	0.30 ± 0.05	0.34 ± 0.03	0.33 ± 0.02
Cmax (μg/mL)	2.33 ± 1.17	4.82 ± 1.23b	2.18 ± 1.14
VFC (μg/mL)	2.81 ± 1.30	2.03 ± 0.58	2.19 ± 0.98

^aP < 0.01 vs healthy rabbit.