Anticipation phenomenon in familial adenomatous polyposis: an analysis of its origin

Table 2 The proportion of causes of death in each generation and their mean age at death (each number of deaths is shown as a proportion to the number of FAP deaths)

Generation	FAP	Extra colonic malignancies	Other diseases	Unknown cause	Death in childhood
Parent	1.00*	0.37	1.24	0.84b	0.78
n = 1952	(50.9 ± 12.4)	(57.6 ± 14.4)	(58.2 ± 19.6)	(36.7 ± 19.8)a
Proband	1.00	0.11	0.37	0.19	0.84
n = 1687	(42.3 ± 12.3)	(46.2 ± 15.8)	(36.7 ± 19.0)	(22.7 ± 16.7)
Child	1.00	0.13	0.44	0.14	1.53
n = 252	(33.3 ± 8.8)	(26.2 ± 16.3)	(22.9 ± 14.2)	(21.9 ± 14.2)

FAP: Death from familial adenomatous polyposis and colorectal cancer. n: Total number of deaths.

^*: Deaths from FAP were calculated as 1.00. (^-x±s, years): Age at death.

^aP < 0.05, vs other causes of death;

^bP < 0.001, vs other two generations.