Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs

Table 2 Effects of CCK-8 on the mean contractile amplitude of body and antrum, and the motility index of pylorus in guinea pigs

Part of stomach		CCK-8	CCK-8 + secretin	Atropine and CCK-8		Indomethacin and CCK-8
Body	LM	-10.3 ± 3.3a	-8.4 ± 3.4a	-17.1 ± 4.8b	1.5 ± 2.1	-8.6 ± 2.7a	-9.7 ± 3.3a
		(n = 19)	(n = 17)	(n = 17)	(n=17)	(n=16)	(n = 16)
	CM	-2.3 ± 2.3	0	-23.3 ± 6.6b	0	0	0
		(n = 11)	(n = 13)	(n = 15)	(n = 15)	(n = 14)	(n = 14)
Antrum	LM	-10.5 ± 4.6a	-9.9 ± 4.3a	-22.2 ± 5.9b	-12.3 ± 4.8a	-8.2 ± 2.6a	-10.0 ± 2.9a
		(n = 13)	(n = 15)	(n = 14)	(n = 14)	(n = 14)	(n = 14)
	CM	58.6 ± 18.1a	48.8 ± 10.8b	-15.7 ± 5.4a	49.8 ± 11.6b	0	45.6 ± 6.6b
		(n = 11)	(n = 17)	(n = 14)	(n = 14)	(n = 16)	(n = 16)
Pylorus	CM	145.0 ± 23.8a	162.5 ± 31.7a	-41.9 ± 12.2a	161.5 ± 55.0a	0	140.0 ± 21.9b
		(n = 10)	(n = 12)	(n = 13)	(n = 13)	(n = 10)	(n = 10)

L(C)M, longitudinal (circular) muscle; dose: CCK-8 10^-2μmol/L, secretin 10^-2μmol/L; atropine 10^-2 mmol/L, indomethacin 10^-2 mmol/ L;

^aP < 0.05,

^bP < 0.01 vs control; 0, no effect; ^-x ± s_x% increase.