Stereoselective propranolol metabolism in two drug induced rat hepatic microsomes

Table 2 Ratio of R( + )/S( - ) propranolol concentration in incubation m edia at different incubation time

Group	Ratio of R( + )/S( - ) propranolol
	0	5	10	15	20	30 (min)
Control	0.989	9.99 ± 0.07	1.01 ± 0.10	1.02 ± 0.02	1.04 ± 0.04	1.07 ± 0.02
BNF	0.989	0.94 ± 0.05	0.93 ± 0.06	0.93 ± 0.04a	0.95 ± 0.05c	0.91 ± 0.05bc
PB	0.989	1.05 ± 0.06	1.04 ± 0.08	1.05 ± 0.10	1.09 ± 0.05	1.09 ± 0.06

Values were obtained from propranolol concentration at 120 μmol/L for each enantiomer, BNF and PB: microsomes from the rats induced with BNF (β-naphthoflavone) or (phenobarbital) 80 mg/(kg·d), ip, 3 d, respectively. ^-x ± s, n = 3.

^aP < 0.05,

^bP < 0.01, compared with control;

^cP < 0.05, compared with PB by unpaired t test.