Protective effect of Irsogladine on monochloramine induced gastric mucosal lesions in rats: a comparative study with rebamipide

Figure 2 Effects of indomethacin and L-NAME on the mucosal protective action of irsogladine and rebamipide against NH₂Cl-induced gastric lesions in rats. The animals were administered po with 1 mL of NH₂Cl (120 mM), and sacrificed 1 h later. Irsogladine (3 mg/kg) or rebamipide (100 mg/kg) was given po 30 min before NH₂Cl treat ment. Indomethacin (5 mg/kg, sc) or L-NAME (10 mg/kg, iv) was given 30 or 10 min before the above agents. Data are presented as the mean ± SE from 5-8 rats. Statistically significant difference at P < 0.05; *from the corresponding control (CMC);#from the corresponding value in normal group.