Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma

Table 5 Effect of PG + PGL on VCC, IP₃, [Ca²⁺]i and PKC acti-vity (pmol/min per mg protein) (x^-± s, n = 5)

Group	PG (mg/L)	PGL (mg/L)	VCC (A)	IP3 (CPM)	[Ca2+]i(nM)	Plasma PKC	Membrane PKC
Control	0.00	0.00	1.554 ± 0.009	8.83 ± 1.33	26.36 ± 2.91	2.39 ± 1.30	1.07 ± 0.28
PG	25.00	0.00	1.580 ± 0.011b	16.17 ± 0.75b	101.44 ± 2.49b	0.91 ± 0.34a	2.65 ± 0.21a
PG + PGL	25.00	8.00	1.553 ± 0.016d
	25.00	16.00	1.551 ± 0.008d	9.17 ± 1.47d	32.63 ± 2.86d	2.33 ± 0.29c	1.05 ± 0.09c
	25.00	32.00	1.546 ± 0.011d	9.00 ± 1.58d	31.79 ± 4.41d	2.30 ± 0.61c	1.05 ± 0.20c
	25.00	64.00	1.549 ± 0.011d	9.33 ± 1.97d	32.45 ± 2.46d	2.32 ± 0.17c	1.09 ± 0.12c
	25.00	128.00	1.549 ± 0.014d

^aP < 0.05,

^bP < 0.01 vs control group;

^cP < 0.05,

^dP < 0.01 vs PG group.