Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma

Table 4 Effect of PG on VCC, IP₃, [Ca²⁺] and PKC activity (pmol/min per mg protein) (x^-± s, n = 5)

Group (mg/L)	VCC (A)	IP3 (CPM)	[Ca2+] I(nM)	Plasma PKC	Membrane PKC
Control	1.554 ± 0.009	8.83 ± 1.33	26.36 ± 2.91	2.39 ± 1.30	1.07 ± 0.28
PG6.25	1.555 ± 0.005	10.16 ± 1.33	30.16 ± 2.16	2.36 ± 0.84	1.09 ± 0.16
12.50	1.563 ± 0.010a	11.18 ± 0.75a	50.69 ± 2.30a	2.30 ± 0.45	1.15 ± 0.15
25.00	1.580 ± 0.011b	16.17 ± 0.75b	101.44 ± 2.49b	0.91 ± 0.34a	2.65 ± 1.21a
50.00	1.579 ± 0.008b	14.10 ± 1.60b	70.63 ± 4.17b	0.92 ± 0.26a	2.65 ± 0.60a
100.00	1.578 ± 0.010b	13.00 ± 2.53b	62.59 ± 2.59b	0.91 ± 0.14a	2.66 ± 0.68a

^aP < 0.05,

^bP < 0.01 vs control group.