Long-term efficacy of plasma-derived hepatitis B vaccine among Chinese children: a 12-year follow-up study

Table 1 Testing methods and diagnosis of HBV infections and immunologic response

Time of testing	Methods and criteria of diagnosis			Manufecturer
	HBsAg	Anti-HBc	Anti-HBs
Before and 6-month,	RPHA	PHA	RIA,S/Nratios	Beijing Institute of
1-year after vaccination	≥ 1:8	≥ 1:8	≥ 2.1	BiologicalProducts
2 to 10 years	RIA, S/N ratios	RIA, inhibitory	RIA,S/Nratios	Beijing Institute of
after vaccination	≥ 2.1	ratios ≥ 75%	≥ 2.1	BiologicalProducts
12 years after	RIA, S/N ratios	RIA, inhibitory	RIA,S/Nratios	Abbot,
vaccination	≥ 2.1	Ratios ≥ 75%	≥ 2.1	USA

S/N ratio: sample to negative control ratio, RIA: radioimmunoassays , RPHA: reverse passive hemagglutination, PHA: passive hemagglutination