Current medical therapy for ulcerative colitis

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Feb 15, 1999 (publication date) through Dec 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 15, 1999; 5(1): 64-72
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.64

Table 4 Immunosuppressives used in inflammatory bowel diseases

Drug	Mode of action	Mechanism of action
AZT/6-MP	Inhibition of ribonucleotide sysnthesis	Inhibition of proliferation of T-cell clones
Methotrexate	Folic acid inhibitor	Inhibition of T and B-cell
		Function decrease of IL-1 and IL-6
Cyclosporin (CsA	Inhibition of T-cell-receptor-stimulated	Inhibition of IL-2 production and
Tacolimua (FK 506)	Transcription of lymphokine genes	IL-2 receptors; inhibition of cytokines(TNFα, IFNγ)
Mycophenolate	Inhibition of guanosin nucleotide synthesis

Citation: Xu CT, Pan BR. Current medical therapy for ulcerative colitis. World J Gastroenterol 1999; 5(1): 64-72
URL: https://www.wjgnet.com/1007-9327/full/v5/i1/64.htm
DOI: https://dx.doi.org/10.3748/wjg.v5.i1.64