Published online Oct 15, 1998. doi: 10.3748/wjg.v4.iSuppl2.62
Revised: August 9, 1998
Accepted: August 27, 1998
Published online: October 15, 1998
AIM: To observe the effects of jaundice relieving and enzyme reduction by Chinese Medicine compound oriental wormwood injection (COWI) on toxic injury of liver in rats.
METHODS: The toxic liver injury models of rats were induced by intragastric perfusion of α-naphthalin-isothiocyanateyl (75 mg/kg·wk). Then models of rats were treated with COWI of three different doses (5 mL/kg·d, 10 mL/kg·d, 15mL/kg·d, respectively) sc. COWI consisted of oriental wormwood, capejasmine, coptis, gentian, scutellaria and rhubarb. COWI originally has the effects of heat-clearing, detoxication, purging of fire and elimination of dampness. Serum alinine aminotransferase (SALT) and serum total bilirubin (STBIL) were measured at 24 h, 48 h, 72 h respectively after treatment with COWI on toxic injury of liver in rats.
RESULTS: Average levels of SALT and STBIL of treatment groups of three different doses were significantly lower compared with control groups (P < 0.05). The group treated with a dose of 15 mL/kg·d for 72 h achieved the best result comparably.
CONCLUSION: (1) The results demonstrate that COWI have effects of relieving jaundice and reducing SALT. (2) COWI is a treatment of choice for acute icteric hepatitis.
- Citation: Chen DY, Lei B, Li HM, Zhang SG, Wei ZM, Cai GM, Zhang JL. Experimental research of jaundice relieving and enzyme reduction by Chinese medicine compound oriental wormwood injection on toxic injury of liver in rats. World J Gastroenterol 1998; 4(Suppl2): 62-62
- URL: https://www.wjgnet.com/1007-9327/full/v4/iSuppl2/62.htm
- DOI: https://dx.doi.org/10.3748/wjg.v4.iSuppl2.62
E- Editor: Li RF