Sequencing of PCR amplified HBV DNA pre-c and c regions in the 2.2.15 cells and antiviral action by targeted antisense oligonucleotide directed against sequence

Table 1 Effect of antisense DNA on HBsAg and HBeAg synthesis in the 2.2.15 cells (P/N value ^-x±s)

Treatment	HBsAg	Inhibitory rate (%)	HBeAg	Inhibitory rate (%)
Untreated control	9.40 ± 0.16		15.10 ± 0.15
Antisense DNA alone	4.30 ± 0.25	70	7.60 ± 1.10	58
Complexed antisense DNA	2.40 ± 0.26	96	4.50 ± 0.42	82
Complexed random DNA	8.10 ± 0.13	19	13.80 ± 0.76	10